Du Jianxiu, Li Yinhuan, Lu Jiuru
Department of Chemistry, School of Chemistry and Material Science, Shaanxi Normal University, Xi'an, People's Republic of China.
Luminescence. 2002 May-Jun;17(3):165-7. doi: 10.1002/bio.685.
A new flow injection chemiluminescence method is described for the determination of captopril. It is based on the enhancing effect of captopril on the chemiluminescence reaction of luminol with potassium ferricyanide in alkaline solution in the presence of potassium ferrocyanide. The method allows the determination of captopril over 0.1-40 microg/mL range, with a relative standard deviation (SD) of 1.0% for the determination of 0.5 microg/mL captopril solution in 11 repeated measurements. The method was satisfactorily applied to the determination of captopril in commercial captopril tablets. The possible reaction mechanism is also discussed briefly.
描述了一种用于测定卡托普利的新型流动注射化学发光方法。它基于在碱性溶液中，亚铁氰化钾存在下，卡托普利对鲁米诺与铁氰化钾化学发光反应的增强作用。该方法可测定0.1 - 40微克/毫升范围内的卡托普利，对0.5微克/毫升卡托普利溶液进行11次重复测定时，相对标准偏差（SD）为1.0%。该方法成功应用于市售卡托普利片剂中卡托普利的测定。还简要讨论了可能的反应机理。
