Chen Xin, Xing Li-Li, Tang Yu-Hai, Zhang Guang-Bin
The 405 Hospital of Hanzhong City, Hanzhong, Shaanxi 723312, China.
Institute of Analytical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
J Pharm Anal. 2013 Apr;3(2):127-131. doi: 10.1016/j.jpha.2012.07.002. Epub 2012 Jul 10.
A rapid and sensitive flow-injection chemiluminescence (CL) method for the determination of glipizide was developed on the basis of finding that glipizide can enhance the CL intensity of the luminol-KFe(CN) system. In optimum condition, the increased CL intensity was directly proportional to the concentration of glipizide in the range from 4.0×10 g/mL to 1.0×10 g/mL and the detection limit was 1.0×10 g/mL glipizide. The relative standard deviation (RSD) of the developed method was 2.1% with 11 repeated measurements of 1.0×10 g/mL glipizide. The developed method has been successfully applied to the analysis of glipizide in its pharmaceutical preparations.
基于发现格列吡嗪能增强鲁米诺 - 铁氰化钾体系的化学发光强度，开发了一种快速灵敏的流动注射化学发光（CL）法用于测定格列吡嗪。在最佳条件下，化学发光强度的增加值与格列吡嗪浓度在4.0×10⁻⁹g/mL至1.0×10⁻⁷g/mL范围内成正比，检测限为1.0×10⁻⁹g/mL格列吡嗪。对1.0×10⁻⁸g/mL格列吡嗪进行11次重复测量，该方法的相对标准偏差（RSD）为2.1%。所开发的方法已成功应用于格列吡嗪药物制剂的分析。
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