Donini L M, de Felice M R, Tassi L, de Bernardini L, Pinto A, Giusti A M, Cannella C
Istituto di Scienza dell'Alimentazione dell'Università di Roma La Sapienza, Italy.
J Nutr Health Aging. 2002;6(2):141-6.
In a previous study we tested the predictive value of the Mini Nutritional Assessment (MNA) in an Italian population of frail elderly in long-term hospital care. The results of our study confirmed the MNA's excellent overall predictive value and sensitivity. Unfortunately we had a large number of false positive judgments, hence our study's low specificity, which we think was caused by two factors: 1. in most cases it was impossible to conduct a reliable subjective assessment of the patients' nutritional and health status. 2. most patients failed to respond to some of the MNA questions, which as a consequence received a "0" score. The result was an artificially low global MNA score even in well-nourished patients.
We tried to neutralize the effects of the defective answers by modifying the total score and the cut-off points of the test. Thus, we: 1. replaced the subjective assessment of health and nutritional status with an objective evaluation; 2. replaced the total score of MNA with the ratio of this value with the maximum of points that each subject can obtain without including the items for which we could not have a response. Similarly, the cut-off points (17 and 24) were replaced with the ratio of these values with the maximum of points obtainable by a complete MNA (30). Patients are classified as "malnourished" below 0.56, "at risk of malnutrition" between 0.56 and 0.79, and "well-nourished" from 0.8 up.
This way, the overall predictive value of MNA is increased from 80.3 to 85.4% and the specificity from 12.8 to 25%, whereas the sensitivity increase is modest (from 98 to 98.1%).
在之前的一项研究中,我们测试了微型营养评定法(MNA)在意大利长期住院护理的体弱老年人群中的预测价值。我们的研究结果证实了MNA具有出色的总体预测价值和敏感性。不幸的是,我们有大量的假阳性判断,因此我们研究的特异性较低,我们认为这是由两个因素造成的:1. 在大多数情况下,不可能对患者的营养和健康状况进行可靠的主观评估。2. 大多数患者未能回答MNA的一些问题,因此这些问题得“0”分。结果是,即使是营养良好的患者,其MNA总体得分也被人为降低。
我们试图通过修改测试的总分和临界点来抵消有缺陷答案的影响。因此,我们:1. 用客观评估取代对健康和营养状况的主观评估;2. 用该值与每个受试者在不包括我们无法得到回答的项目情况下所能获得的最高分的比值取代MNA的总分。同样,临界点(17和24)被这些值与完整MNA可获得的最高分(30)的比值所取代。患者被分类为:低于0.56为“营养不良”,在0.56至0.79之间为“有营养不良风险”,0.8及以上为“营养良好”。
通过这种方式,MNA的总体预测价值从80.3%提高到85.4%,特异性从12.8%提高到25%,而敏感性提高幅度不大(从98%提高到98.1%)。