Maj Mario, Pirozzi Raffaele, Bartoli Luca, Magliano Lorenza
Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, I-80138 Napoli, Italy.
J Affect Disord. 2002 Sep;71(1-3):195-8. doi: 10.1016/s0165-0327(01)00350-0.
No study has assessed systematically up to now the long-term outcome of lithium prophylaxis in bipolar patients with vs. without mood-incongruent psychotic features.
All bipolar patients with mood-incongruent psychotic features who started lithium prophylaxis at a lithium clinic during 14 years were followed up prospectively for 5 years, along with a control group of non-psychotic bipolars.
Psychotic patients were significantly less likely than controls to be still on lithium after 5 years, and to present a reduction of at least 50% of time spent in hospital during the lithium treatment period compared with a pre-treatment period of the same duration. The time to 50% risk of readmission was significantly increased among both groups during lithium treatment. 39.6% of prospective episodes in psychotic patients did not include mood-incongruent psychotic features.
This is a naturalistic study carried out at a lithium clinic. No control group of bipolar patients who did not receive lithium was available.
Lithium exerts a significant impact on the course of bipolar disorder with mood-incongruent psychotic features, although this impact is less pronounced than in classical manic-depressive illness.
迄今为止，尚无研究系统评估有或无心境不和谐精神病性特征的双相情感障碍患者接受锂盐预防性治疗的长期疗效。
对14年间在一家锂盐治疗诊所开始接受锂盐预防性治疗的所有伴有心境不和谐精神病性特征的双相情感障碍患者进行了为期5年的前瞻性随访，并设立了一个非精神病性双相情感障碍患者对照组。
5年后，与对照组相比，精神病性患者仍在接受锂盐治疗的可能性显著降低，且与相同时长的治疗前相比，锂盐治疗期间住院时间至少减少50%。两组在锂盐治疗期间再次入院风险达到50%的时间均显著延长。精神病性患者39.6%的前瞻性发作未出现心境不和谐精神病性特征。
这是在一家锂盐治疗诊所开展的一项自然主义研究。没有未接受锂盐治疗的双相情感障碍患者对照组。
锂盐对伴有心境不和谐精神病性特征的双相情感障碍病程有显著影响，尽管这种影响不如经典躁狂抑郁症明显。
