Thongnest Sanit, Boonsombat Jutatip, Prawat Hunsa, Mahidol Chulabhorn, Ruchirawat Somsak
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Phytochemistry. 2017 Feb;134:98-105. doi: 10.1016/j.phytochem.2016.11.007. Epub 2016 Nov 25.
Bioactivity-guided chemical investigation of the CHCl and CHClMeOH extracts of the stem and stem bark material of Ailanthus tryphysa (Simaroubaceae) led to the isolation of five cycloapotirucallanes, ailanthusins A-E, two malabaricanes, ailanthusins F-G, and one nor-lupane triterpenoid, 29-nor-lup-1-ene-3,20-dione along with twenty known compounds. Their structures were elucidated through the application of extensive spectroscopic methods, and the structure of ailanthusin A was further confirmed by single crystal X-ray analysis. Several malabaricane derivatives were prepared from malabaricol and, together with some of the isolates, were evaluated for their cytotoxic activities against human cancer and normal cell lines.
对臭椿（苦木科）茎和茎皮材料的CHCl和CHClMeOH提取物进行生物活性导向的化学研究，分离得到了五种环阿朴羽扇豆烷型化合物，即臭椿素A - E，两种马拉巴烷型化合物，臭椿素F - G，以及一种降羽扇豆烷型三萜化合物，29 - 降羽扇豆 - 1 - 烯 - 3,20 - 二酮，同时还得到了二十种已知化合物。通过广泛应用光谱方法阐明了它们的结构，臭椿素A的结构通过单晶X射线分析进一步得到确证。从马拉巴醇制备了几种马拉巴烷衍生物，并与一些分离物一起对人癌细胞系和正常细胞系进行了细胞毒性活性评价。
