Uebe Barbara, Sauerbrei Andreas, Burdach Stefan, Horneff Gerd
Department of Paediatrics, University Hospital, Martin-Luther University Halle-Wittenberg, 06097 Halle, Germany.
Eur J Pediatr. 2002 Aug;161(8):442-4. doi: 10.1007/s00431-002-0981-1. Epub 2002 Jun 25.
Varicella can be prevented by vaccination using the live-attenuated Oka vaccine strain of varicella zoster virus (VZV). Only mild breakthrough disease has been reported in seronegative vaccinees when exposed to the wild-type virus. The latent varicella vaccine virus has rarely caused herpes zoster in childhood and adolescence. We report a healthy 2-year-old girl who developed an impressive herpes zoster infection 16 months after vaccination, localised in three cervical dermatoma. As causative virus, VZV vaccine strain was identified by polymerase chain reaction and analysis of restriction fragment length polymorphisms of the amplified products.
vaccine varicella zoster virus can occasionally reactivate in healthy children and present as herpes zoster. Virus characterisation is necessary to identify the strain and provide information on the incidence of occurrence.
水痘可通过接种水痘带状疱疹病毒（VZV）减毒活Oka疫苗株来预防。血清阴性的接种者在接触野生型病毒时，仅报告有轻微的突破性疾病。潜伏的水痘疫苗病毒在儿童和青少年中很少引起带状疱疹。我们报告一名健康的2岁女孩，在接种疫苗16个月后发生了令人印象深刻的带状疱疹感染，病变局限于三个颈部皮肤区。通过聚合酶链反应和对扩增产物的限制性片段长度多态性分析，鉴定出VZV疫苗株为致病病毒。
疫苗水痘带状疱疹病毒偶尔可在健康儿童中重新激活并表现为带状疱疹。病毒特征鉴定对于识别毒株和提供发病发生率信息是必要的。
