Grigor'eva O N, Gusel' V A
Zh Evol Biokhim Fiziol. 1975 Sep-Oct;11(5):497-502.
In experiments on 6-10, 16-20-day and adult rabbits, electrochimiotrodes were chronically implanted into the dorsal hippocamp. Direct application of a M-cholinolytic, metamizyl, or N-cholinolytic, gangleron, to penicillin-induced epileptogenic zone in the hippocamp inhibited seizures in rabbits of all age groups. The intensity of interseizure epileptiform discharges in the EEG did not change under the action of cholinolytics in adult and 6-10-day rabbits, and decreased in 16-20-day ones. Parenteral administration of gangleron caused the same effect on the activity of epileptogenic zone, as its direct application to the hippocamp. Parenteral administration of metamizyl inhibited seizures in young animals (similarly to its direct application to the hippocamp), but increased the seizures and interseizure discharges in adult rabbits. Therefore, already to the 6th day of postnatal life of rabbits, blocking of the cholinoreactive system of the hippocamp may inhibit circulation of seizural discharges along closed neuronal circuits, which is necessary for the formation of the seizure.
在对6 - 10日龄、16 - 20日龄和成年家兔进行的实验中，将电化学电极长期植入背侧海马体。将M - 胆碱能阻断剂美他环素或N - 胆碱能阻断剂甘罗溴铵直接应用于海马体中青霉素诱导的致痫区，可抑制所有年龄组家兔的癫痫发作。在成年和6 - 10日龄家兔中，脑电图中发作间期癫痫样放电的强度在胆碱能阻断剂作用下未发生变化，而在16 - 20日龄家兔中则有所降低。甘罗溴铵的肠胃外给药对致痫区活动产生的影响与其直接应用于海马体时相同。美他环素的肠胃外给药在幼龄动物中抑制癫痫发作（类似于其直接应用于海马体），但在成年家兔中增加了癫痫发作和发作间期放电。因此，在出生后第6天，阻断海马体的胆碱反应系统可能会抑制癫痫样放电在封闭神经元回路中的循环，而这种循环对于癫痫发作的形成是必要的。
