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[M型和N型拟胆碱药对不同年龄家兔海马致痫灶活动的影响]

[Effect of M- and N-cholinomimetics on the activity of an epileptogenic focus in the hippocampus of rabbits of different ages].

作者信息

Gusel V A, Grigoreva O N

出版信息

Zh Evol Biokhim Fiziol. 1976 Sep-Oct;12(5):455-60.

PMID:983571
Abstract

Experiments have been made on adult, 16-20 and 6-10 day old rabbits with electrodes chronically implanted into the left and right dorsal hippocamp. Solutions of arecoline (M-cholinomimetic) and nicotine (N-cholinomimetic) were administered into the penicillin epileptogenic focus of the hippocamp. Large doses of arecoline (10 mg) and nicotine (0.5 mg) did not affect the epileptiform discharges in the EEG, but inhibited the fits in adult and 16-20 day old rabbits...

摘要

已对成年、16 - 20日龄和6 - 10日龄的兔子进行了实验，将电极长期植入左右背侧海马体。将槟榔碱（M - 拟胆碱药）和尼古丁（N - 拟胆碱药）溶液注入海马体的青霉素致痫灶。大剂量的槟榔碱（10毫克）和尼古丁（0.5毫克）对脑电图中的癫痫样放电没有影响，但抑制了成年和16 - 20日龄兔子的癫痫发作……

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Zh Evol Biokhim Fiziol. 1976 Sep-Oct;12(5):455-60.
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