Tkachenko E I, Losev N A
Biull Eksp Biol Med. 1983 May;95(5):23-5.
It has been shown in chronic experiments on rabbits with epileptogenic foci provoked by microinjections of penicillin into the dorsal hippocamp that the N-cholinoblockers gangleron (3 mg/k, intravenously) and etherophen (5-10mg/kg, intravenously) possess marked anticonvulsant activity. Diphenin (50 mg/kg, intraperitoneally) was less potent. The M-cholinoblocker methamizil (1 mg/kg, intravenously), on the contrary, potentiated the epileptiform seizures. Emphasis is laid on the necessity of the goal-oriented synthesis and search for agents that would exhibit a "purely" central N-cholinoblocking action with a purpose of applying such agents as antiepileptic drugs. It is not recommended using the M-cholinoblockers for such purposes.
在对通过向背侧海马微量注射青霉素诱发癫痫病灶的兔子进行的慢性实验中发现，N - 胆碱阻滞剂甘罗溴铵（3毫克/千克，静脉注射）和乙磺半胱氨酸（5 - 10毫克/千克，静脉注射）具有显著的抗惊厥活性。苯妥英（50毫克/千克，腹腔注射）的效力较弱。相反，M - 胆碱阻滞剂美他环素（1毫克/千克，静脉注射）会增强癫痫样发作。强调了有必要进行目标导向的合成并寻找具有“纯粹”中枢N - 胆碱阻滞作用的药物，以便将此类药物用作抗癫痫药物。不建议将M - 胆碱阻滞剂用于此目的。
