Wissing S, Müller R
Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Kelchstr. 31, 12169, Berlin, Germany.
Int J Pharm. 2002 Aug 21;242(1-2):373-5. doi: 10.1016/s0378-5173(02)00219-3.
The aim of this study was the in vitro evaluation of the efficacy of two different carrier systems for the molecular sunscreen benzophenone-3. One carrier system was a conventional o/w emulsion, the other consisted of highly crystalline lipid nanoparticles (CLN). It was observed that CLN act as physical sunscreens themselves and show improved photoprotection compared with a placebo emulsion with the same lipid content. Incorporation of a molecular sunscreen further improves the protection level in a synergistic way. This in vitro study based on the Transpore test by Diffey showed that the amount of molecular sunscreen can be decreased by up to 50% while maintaining the UV protection efficacy. Therefore, the use of CLN as an active carrier for sunscreens is a promising innovation.
本研究的目的是对两种不同载体系统用于分子防晒剂二苯甲酮 -3 的体外功效进行评估。一种载体系统是传统的水包油乳液，另一种由高度结晶的脂质纳米颗粒（CLN）组成。据观察，CLN 本身可作为物理防晒剂，与具有相同脂质含量的安慰剂乳液相比，其光防护性能有所提高。加入分子防晒剂可通过协同作用进一步提高防护水平。这项基于 Diffey 的透孔试验的体外研究表明，在保持紫外线防护功效的同时，分子防晒剂的用量可减少高达 50%。因此，将 CLN 用作防晒剂的活性载体是一项有前景的创新。
