Song Chunjin, Liu Shuangxi
Chemistry College, Nankai University, 94 Weijin Road, Tianjin 300071, PR China.
Int J Biol Macromol. 2005 Jul;36(1-2):116-9. doi: 10.1016/j.ijbiomac.2005.05.003.
The aim of this study was to find safer cosmetics for human through application chitin and natural solid lipsomes to sunscreen. Pure chitin is not solved completely in majority chemical agents and traditional chemical UV blockers are potentially harmful to human skin. So the combination of chemical UV absorber and chitin formed 3,4,5-trimethoxybenzoylchitin (TMBC), which was proven as an active chemical sunscreen by Dr. Clausen, and can overcome their inherent defects. Lipophilic ability of the new material can be increased while harmfulness can be decreased due to incorporation natural material chitin. Then solid lipid nanoparticles (SLN) loaded with TMBC to act both as physical sunscreens themselves and as carriers in order to enhance the effect of UVB protection. The improvement of the system can been observed when tocopherol was added.
本研究的目的是通过将几丁质和天然固体脂质体应用于防晒霜，找到对人类更安全的化妆品。纯几丁质在大多数化学试剂中不能完全溶解，传统的化学紫外线阻断剂可能对人体皮肤有害。因此，化学紫外线吸收剂与几丁质结合形成了3,4,5-三甲氧基苯甲酰几丁质（TMBC），克劳森博士证明其为一种活性化学防晒剂，并且可以克服其固有缺陷。由于加入了天然材料几丁质，这种新材料的亲脂性可以提高，同时危害性可以降低。然后将负载TMBC的固体脂质纳米粒（SLN）用作物理防晒霜并作为载体，以增强UVB防护效果。添加生育酚时，可以观察到该体系的改善。
