Department of Pharmaceutics, Biopharmaceutics and Quality Management, Institute of Pharmacy, Free University of Berlin, Kelchstrasse 31, 12169 Berlin, Germany.
Int J Pharm. 2011 Jul 29;414(1-2):276-84. doi: 10.1016/j.ijpharm.2011.05.010. Epub 2011 May 10.
A photoprotective formulation was developed with an increased sunprotection factor (SPF), compared to a conventional nanoemulsion, but having the same concentration of three molecular sunscreens, namely ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, and ethylhexyl methoxycinnamate. The sunscreen mixture was incorporated into nanostructured lipid carriers (NLCs). The ability of nine different solid lipids to yield stable aqueous NLC suspensions was assessed. After the production by hot high pressure homogenization, the NLC were analyzed in terms of particle size, physical state, particle shape, ultraviolet absorbance and stability. The particle size for all NLC was around 200 nm after production. The NLC suspension with carnauba wax had superior UV absorbance, NLC from bees wax showed similar efficiency as the reference emulsion. The NLC formulations were incorporated into hydrogel formulations and the in vitro SPF was measured. This study demonstrated that approximately 45% higher SPF values could be obtained when the organic UV filters were incorporated into carnauba wax NLC, in comparison to the reference nanoemulsion and bees wax NLC. The data showed that the synergistic effect of NLC and incorporated sunscreens depends not only on the solid state of the lipid but also on its type.
一种光保护配方的防晒因子（SPF）得到了提高，与传统的纳米乳液相比，但含有相同浓度的三种分子防晒霜，即乙基己基三嗪、双-乙基己氧基苯酚甲氧基二苯并恶嗪和乙基己基甲氧基肉桂酸酯。防晒霜混合物被掺入纳米结构脂质载体（NLC）中。评估了九种不同固体脂质产生稳定水性 NLC 悬浮液的能力。通过热高压匀浆生产后，从粒径、物理状态、颗粒形状、紫外线吸收和稳定性方面对 NLC 进行了分析。所有 NLC 的粒径在生产后约为 200nm。含有巴西棕榈蜡的 NLC 悬浮液具有更好的紫外线吸收能力，蜂蜡 NLC 的效率与参考乳液相似。将 NLC 制剂掺入水凝胶制剂中，并测量体外 SPF。本研究表明，与参考纳米乳液和蜂蜡 NLC 相比，当有机紫外线滤光剂掺入巴西棕榈蜡 NLC 中时，可获得约 45%更高的 SPF 值。数据表明，NLC 和掺入的防晒霜的协同效应不仅取决于脂质的固体状态，还取决于其类型。
