Wissing Sylvia A, Müller Rainer H
Institut für Pharmazie, Pharmazeutische Technologie, Biopharmazie und Biotechnologie, Freie Universität Berlin, Kelchstrasse 31, D-12169 Berlin, Germany.
Int J Pharm. 2003 Mar 18;254(1):65-8. doi: 10.1016/s0378-5173(02)00684-1.
Solid lipid nanoparticles (SLN) are novel delivery systems for pharmaceutical and cosmetic active ingredients. This paper highlights advantages of SLN for cosmetic applications. The dependence of the occlusive effect on the particle size of SLN due to film formation is presented by in vitro data. An in vivo study showed that addition of 4% SLN to a conventional o/w cream lead to an increase of skin hydration of 31% after 4 weeks. The application of SLN as physical sunscreens and as active carriers for molecular sunscreens has also been investigated. The amount of molecular sunscreen could be decreased by 50% while maintaining the protection level compared to a conventional emulsion.
固体脂质纳米粒（SLN）是用于药物和化妆品活性成分的新型递送系统。本文重点介绍了SLN在化妆品应用中的优势。体外数据表明了由于成膜作用，封闭效果对SLN粒径的依赖性。一项体内研究表明，在传统的水包油型乳膏中添加4%的SLN，4周后皮肤水合作用增加了31%。还研究了SLN作为物理防晒剂和分子防晒剂活性载体的应用。与传统乳液相比，在保持保护水平的同时，分子防晒剂的用量可减少50%。
