Gasser J C, Bellville J W
Anaesthesist. 1975 Dec;24(12):526-8.
A 2X2 factorially designed study has been done to determine the respiratory effects of pentazocine and doxapram in terms of the minute ventilation end-expiratory PCO2 response curve. Pentazocine 30 mg intramuscularly produced marked respiratory depression. Doxapram 60 mg intramuscularly produced significant respiratory stimulation. When this dose of doxapram was given in combination with 30 mg pentazocine it produced significant reduction in the amount of respiratory depression induced by the narcotic. The statistical analysis did not show that there was anything to suggest this effect was more than additive.
已进行了一项2×2析因设计研究，以根据分钟通气量-呼气末二氧化碳反应曲线来确定喷他佐辛和多沙普仑的呼吸效应。肌肉注射30毫克喷他佐辛会产生明显的呼吸抑制。肌肉注射60毫克多沙普仑会产生显著的呼吸刺激作用。当将此剂量的多沙普仑与30毫克喷他佐辛联合使用时，它能显著减轻麻醉药引起的呼吸抑制程度。统计分析并未表明有任何迹象表明这种作用不仅仅是相加作用。
