米氏函数的因式分解。
Factorization of the Michaelis functions.
作者信息
Dixon H B
出版信息
Biochem J. 1975 Nov;151(2):271-4. doi: 10.1042/bj1510271.
Each Michaelis function that expresses the concentration of one of the species AL2, AL and A in terms of the concentration of free ligand (or its logarithm) is the product of two functions each of which represents the degree of ligation or de-ligation of a single site. These hypothetical sites have pK values of pK (SEE ARTICLE) where pK and alpha are defined by writing the two molecular pK values as pK +/- log2alpha. The factors are thus real if alpha larger than or equal to 1, i.e. if the binding of L by A is not positively co-operative. The dependence of [AL] on 1n[L] is compared with relations that represent other ligand-dependent equilibria.
每个根据游离配体浓度（或其对数）来表示物种AL2、AL和A之一浓度的米氏函数，都是两个函数的乘积，其中每个函数都代表单个位点的连接或去连接程度。这些假设位点的pK值为pK（见文章），其中pK和α是通过将两个分子pK值写为pK +/- log2α来定义的。因此，如果α大于或等于1，即如果A对L的结合不是正协同的，则这些因子是实数。将[AL]对ln[L]的依赖性与代表其他配体依赖性平衡的关系进行了比较。
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