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本文引用的文献

1
Shapes of curves of pH-dependence of reactions.反应pH依赖性曲线的形状。
Biochem J. 1973 Jan;131(1):149-54. doi: 10.1042/bj1310149.
2
Curves of ligand binding. The use of hyperbolic functions for expressing titration curves.配体结合曲线。使用双曲线函数来表达滴定曲线。
Biochem J. 1974 Mar;137(3):443-7. doi: 10.1042/bj1370443.

pH 控制的氢键作用

pH-controlled hydrogen-bonding.

作者信息

Wood J L

出版信息

Biochem J. 1974 Dec;143(3):775-7. doi: 10.1042/bj1430775.

DOI:10.1042/bj1430775
PMID:4462756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168448/
Abstract

The pH-dependence of the degree of hydrogen-bonding between a base and its conjugate acid is considered. When only a small proportion of the total base is complexed, the amount complexed is proportional to (1+coshp)(-1) where p=2.303 (pK(a)-pH), pK(a) being the dissociation constant of the conjugate acid. This represents sharp pH-dependence. As the proportion complexed increases, the curve broadens, eventually becoming flat-topped, with more than half the base complexed over the range of pH values pK(a)+/-logKC, approximately. (K is the complex association constant and C is the formal base concentration, including all forms.) There are similarities to the extent of mono-protonation of a dibasic acid.

摘要

考虑了碱与其共轭酸之间氢键程度的pH依赖性。当仅一小部分总碱形成络合物时，形成络合物的量与(1 + coshp)(-1)成正比，其中p = 2.303(pK(a)-pH)，pK(a)是共轭酸的解离常数。这表示出强烈的pH依赖性。随着形成络合物的比例增加，曲线变宽，最终变为平顶，在大约pK(a)±logKC的pH值范围内，超过一半的碱形成了络合物。(K是络合缔合常数，C是包括所有形式的形式碱浓度。)这与二元酸的单质子化程度存在相似之处。