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微球菌中一种与膜相关的脂甘露聚糖。

A membrane-associated lipomannan in micrococci.

作者信息

Powell D A, Duckworth M, Baddiley J

出版信息

Biochem J. 1975 Nov;151(2):387-97. doi: 10.1042/bj1510387.

Abstract

Membranes of Micrococcus lysodeikticus, Micrococcus flavus and Micrococcus sodonensis contain acidic lipomannans. Lipoteichoic acids could not be detected in these organisms, and the suggestion that they are substituted for by the lipomannans is strengthened by the chemical and physical resemblances between the two polymers. The mannans contain glycerol, ester-linked fatty acids and mono-esterified succinic acid residues, giving them both hydrophobic and charged properties. The M. lysodeikticus mannan has a chain of about 60 hexose units with two branch points, and is joined at its reducing end to the 1-position of a glycerol moiety bearing two fatty acid residues. Succinic acid on the mannan enables it to bind Mg2+ efficiently, and the polymer is firmly associated with the cytoplasmic membrane, probably by intercalation of its fatty acids with those of the membrane lipids.

摘要

溶壁微球菌、黄微球菌和索氏微球菌的细胞膜含有酸性脂甘露聚糖。在这些微生物中未检测到脂磷壁酸,并且两种聚合物在化学和物理性质上的相似性进一步支持了脂磷壁酸被脂甘露聚糖取代的观点。甘露聚糖含有甘油、酯连接的脂肪酸和单酯化的琥珀酸残基,赋予它们疏水性和带电特性。溶壁微球菌甘露聚糖具有一条约60个己糖单位的链,带有两个分支点,并在其还原端与带有两个脂肪酸残基的甘油部分的1位相连。甘露聚糖上的琥珀酸使其能够有效地结合Mg2+,并且该聚合物可能通过其脂肪酸与膜脂脂肪酸的插入作用而与细胞质膜紧密结合。

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