Lockhoff Oswald, Frappa Isabelle
Bayer AG, Central Research, ZF-WF, Q18, Simon Fraser University, D-51368 Leverkusen, Germany.
Comb Chem High Throughput Screen. 2002 Aug;5(5):361-72. doi: 10.2174/1386207023330219.
Glycobiology opens a wide field for new therapeutic approaches. However, the complexity and unavailability of various carbohydrate test compounds has excluded this class of natural products from modern screening systems. Alternatively, glycomimetics are considered to be more drug-like candidates for development. By means of multicomponent condensations (MCCs) utilizing suitable carbohydrate synthons, rapid and effective access to glycoconjugate libraries can be obtained. The flexibility of MCCs allows the assembly of diverse carbohydrate containing libraries. It may be assumed that MCCs containing carbohydrate moieties will play an important role in glycomimetic chemistry and biology.
糖生物学为新的治疗方法开辟了广阔领域。然而，各种碳水化合物测试化合物的复杂性和难以获取性已将这类天然产物排除在现代筛选系统之外。相比之下，糖模拟物被认为是更具药物开发潜力的候选物。通过利用合适的碳水化合物合成子进行多组分缩合反应（MCCs），可以快速有效地获得糖缀合物文库。MCCs的灵活性使得能够组装各种含碳水化合物的文库。可以推测，含有碳水化合物部分的MCCs将在糖模拟化学和生物学中发挥重要作用。
