体育锻炼与血压：参考血管紧张素原M235T基因多态性

Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism.

作者信息

Rauramaa Rainer, Kuhanen Raimo, Lakka Timo A, Väisänen Sari B, Halonen Pirjo, Alén Markku, Rankinen Tuomo, Bouchard Claude

机构信息

Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, 70100 Kuopio, Finland.

出版信息

Physiol Genomics. 2002 Aug 14;10(2):71-7. doi: 10.1152/physiolgenomics.00050.2002.

DOI:10.1152/physiolgenomics.00050.2002

PMID:12181364

Abstract

We investigated the role of the angiotensinogen (AGT) gene M235T polymorphism in determining blood pressure (BP) response to moderate intensity exercise in a 6-yr randomized controlled trial in 140 middle-aged men. Sitting, supine, and standing blood pressures were measured annually. Of the randomized men, 86% participated in the trial for 6 yr. Submaximal cardiorespiratory fitness increased by 16% in the exercise group. In the M homozygotes, sitting systolic BP decreased by 1.0 mmHg in the exercise but increased by 14.6 mmHg in the reference group (P = 0.007 for net effect). Sitting and supine diastolic BP decreased by 6.2 and 3.3 mmHg in the exercise but increased by 2.8 and 3.2 mmHg in the reference group (P = 0.026 and 0.024 for net effects), respectively. Regular moderate intensity exercise attenuates aging-related increase in systolic BP and decreases diastolic BP among the M homozygotes of the AGT gene M235T polymorphism.

摘要

在一项针对140名中年男性的为期6年的随机对照试验中，我们研究了血管紧张素原（AGT）基因M235T多态性在决定血压（BP）对中等强度运动反应中的作用。每年测量坐位、仰卧位和站立位血压。在随机分组的男性中，86%参与试验达6年。运动组的次最大心肺适能提高了16%。在M纯合子中，运动组坐位收缩压下降了1.0 mmHg，而对照组上升了14.6 mmHg（净效应P = 0.007）。运动组坐位和仰卧位舒张压分别下降了6.2和3.3 mmHg，而对照组分别上升了2.8和3.2 mmHg（净效应P分别为0.026和0.024）。规律的中等强度运动可减弱AGT基因M235T多态性M纯合子中与衰老相关的收缩压升高，并降低舒张压。