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[纹状体切除术对在U型迷宫中重新训练大鼠形成回避习惯的影响]

[The effect of striatectomy on retraining rats to an avoidance habit in a U-shaped maze].

作者信息

Arushanian E B, Baturin V A

出版信息

Biull Eksp Biol Med. 1975 Nov;80(11):5-8.

PMID:1218261
Abstract

The capacity of rats to reversal learning changing of the direction of the avoidance response was determined in the Y-shaped maze. Four training sessions--each time in a new direction (to the right or to the left) for running were conducted in the course of one experiment. The results obtained in 4 groups of animals were compared: intact, with bi- and unilateral striatectomy and with bilateral destruction of the parietal cortex. The majority of the intact rats preferred running in the right direction. The character of the preference changed after striectomy: the rats ran more regularly in the direction at the side of which the striatum was injured more. Bilateral striatectomy also led to increase in the number of errors, to the increase in the latency and disturbance of a passive component of the avoidance response.

摘要

在Y型迷宫中测定大鼠逆转学习(即改变回避反应方向)的能力。在一个实验过程中进行了四次训练——每次在一个新的方向(向右或向左)奔跑。比较了四组动物的实验结果:完整组、双侧和单侧纹状体切除组以及双侧顶叶皮质损毁组。大多数完整的大鼠更喜欢向右奔跑。纹状体切除后偏好的特征发生了变化:大鼠更倾向于朝着纹状体损伤更严重一侧的方向奔跑。双侧纹状体切除还导致错误数量增加、潜伏期延长以及回避反应被动成分的紊乱。

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