[Removal of the optimizing action of neuroleptics on the avoidance behavior of rats after striatectomy].

In an Y-maze rats easier reformed the trajectory of the behavioral response under the effect of haloperidol (0.05--0.1 mg/kg) and aminazin (0.5--1 mg/kg). A restricted (5--10 per cent of the volume) bilateral electrolytic distruction of the striatum fully suppressed the effect of lower doses of the above compounds both early (7--14th day) and late (28--35th day) after the operation. In large doses the neuroleptics continued to facilitate relearning of the rats in the first 1--2 weeks following striatectomy, but later on this effect also disappeared.