Arushanian E B, Baturin V A
Pharmacol Biochem Behav. 1982 Apr;16(4):541-5. doi: 10.1016/0091-3057(82)90411-7.
Haloperidol (0.05-0.1 mg/kg) and chlorpromazine (0.5-1.0 mg/kg) improved reversal learning avoidance responses in a Y-maze, decreased intersessional fluctuations of errors and decreased the number of spontaneous exits from a correctly selected chamber. After bilateral lesions of the striatum this effect disappeared. Brain lesions also attenuated the ability of neuroleptics to suppress amphetamine-induced stereotypy and and accompanying defects in avoidance responses. The improvement of avoidance behavior by neuroleptics may be related to the reduction of spatial preference caused by functional asymmetry between the bilateral nigro-striatal systems.
氟哌啶醇（0.05 - 0.1毫克/千克）和氯丙嗪（0.5 - 1.0毫克/千克）可改善Y迷宫中的逆向学习回避反应，减少各时段间错误波动，并减少从正确选择的隔室中自发离开的次数。纹状体双侧损伤后，这种效应消失。脑部损伤也减弱了抗精神病药物抑制苯丙胺诱导的刻板行为及伴随的回避反应缺陷的能力。抗精神病药物对回避行为的改善可能与双侧黑质纹状体系统功能不对称导致的空间偏好降低有关。
