Guzmán Manuel, Sánchez Cristina, Galve-Roperh Ismael
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.
Pharmacol Ther. 2002 Aug;95(2):175-84. doi: 10.1016/s0163-7258(02)00256-5.
Cannabinoids recently have been shown to control the cell survival/death decision. Thus, cannabinoids induce growth arrest or apoptosis in a number of transformed neural and non-neural cells in culture. In addition, cannabinoid administration induces regression of malignant gliomas in rodents by a mechanism that may involve sustained ceramide generation and extracellular signal-regulated kinase activation. In contrast, most of the experimental evidence indicates that cannabinoids may protect normal neurons from toxic insults, such as glutamatergic overstimulation, ischaemia, and oxidative damage. Regarding immune cells, low doses of cannabinoids may enhance proliferation, whereas high doses of cannabinoids usually induce growth arrest or apoptosis. The potential therapeutic applications of these findings are discussed.
最近研究表明，大麻素能够控制细胞的生存/死亡抉择。因此，大麻素可诱导培养中的多种转化神经细胞和非神经细胞发生生长停滞或凋亡。此外，给予大麻素可使啮齿动物的恶性胶质瘤消退，其机制可能涉及持续生成神经酰胺和激活细胞外信号调节激酶。相比之下，大多数实验证据表明，大麻素可能保护正常神经元免受毒性损伤，如谷氨酸能过度刺激、缺血和氧化损伤。关于免疫细胞，低剂量大麻素可增强其增殖，而高剂量大麻素通常会诱导生长停滞或凋亡。本文讨论了这些研究结果的潜在治疗应用。
