Correa Fernando, Mestre Leyre, Molina-Holgado Eduardo, Arévalo-Martín Angel, Docagne Fabian, Romero Eva, Molina-Holgado Francisco, Borrell José, Guaza Carmen
Neural Plasticity Unit, Neuroimmunology Group, Instituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Mini Rev Med Chem. 2005 Jul;5(7):671-5. doi: 10.2174/1389557054368790.
There is a growing amount of evidence suggesting that cannabinoids may be neuroprotective in CNS inflammatory conditions. Advances in the understanding of the physiology and pharmacology of the cannabinoid system have increased the interest of cannabinoids as potential therapeutic targets. Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in cells of the immune system, as well as in brain glial cells. In the present review it is summarized the effects of cannabinoids on immune reactivity and on the regulation of neuroinflammatory processes associated with brain disorders with special attention to chronic inflammatory demyelinating diseases such as multiple sclerosis.
越来越多的证据表明，大麻素在中枢神经系统炎症性疾病中可能具有神经保护作用。对大麻素系统生理学和药理学认识的进展，增加了人们对大麻素作为潜在治疗靶点的兴趣。在免疫系统细胞以及脑胶质细胞中已检测到大麻素受体及其内源性配体——内源性大麻素。在本综述中，总结了大麻素对免疫反应性以及与脑部疾病相关的神经炎症过程调节的影响，特别关注慢性炎症性脱髓鞘疾病，如多发性硬化症。
