Yenicesu Idil, Yetgin Sevgi, Ozyürek Emel, Aslan Deniz
Department of Paediatric Haematology, New Hope in Health Foundation, ABC Child Health Center, Ankara, Turkey.
Pediatr Hematol Oncol. 2002 Sep;19(6):433-7. doi: 10.1080/08880010290097233.
Idiopathic thrombocytopenic purpura (ITP) in children is usually a self-limiting disorder. It may follow a viral infection or immunization and is caused by an inappropriate response of the immune system. Many viruses, such as human immunodeficiency virus, cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella, rubeola, mumps, and parvovirus, have been implicated in childhood ITP. This study is a retrospective chart review of pediatric patients diagnosed with virus-associated ITP at the Hacettepe University, Ihsan Dogramaci Children's Hospital from 1997 to end of 2000. In viral serological studies, the EBV, CMV, and rubella antibodies were investigated for all patients at diagnosis (ELlSA). The proportion of children whose ITP was associated with documented acute viral infection was 13.3% in this group. In the present study, clinical manifestations and laboratory data of virus-associated or not associated groups are similar except age. Median age of the virus-associated group is younger than that of the other, but it is not statistically significant.
儿童特发性血小板减少性紫癜（ITP）通常是一种自限性疾病。它可能继发于病毒感染或免疫接种之后，由免疫系统的不适当反应引起。许多病毒，如人类免疫缺陷病毒、巨细胞病毒（CMV）、爱泼斯坦-巴尔病毒（EBV）、水痘、麻疹、腮腺炎和风疹病毒，都与儿童ITP有关。本研究是对1997年至2000年底在哈杰泰佩大学伊赫桑·多格拉马西儿童医院被诊断为病毒相关性ITP的儿科患者进行的回顾性病历审查。在病毒血清学研究中，对所有患者在诊断时检测EBV、CMV和风疹抗体（酶联免疫吸附测定法）。该组中ITP与确诊的急性病毒感染相关的儿童比例为13.3%。在本研究中，病毒相关组和非病毒相关组的临床表现和实验室数据相似，年龄除外。病毒相关组的中位年龄比另一组年轻，但差异无统计学意义。
