Zheng Shou-Yan, Xiao Qiu-Yan, Xie Xiao-Hong, Deng Yu, Ren Luo, Tian Dai-Yin, Luo Zheng-Xiu, Luo Jian, Fu Zhou, Huang Ai-Long, Liu En-Mei
Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China.
Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Sci Rep. 2016 Mar 11;6:22964. doi: 10.1038/srep22964.
Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and secondary thrombocytosis were analyzed retrospectively. The blood platelet count and the presence of respiratory viruses were determined for 3156 RTI patients, and 817 (25.9%) cases with platelet ≥500 × 10(9)/L were considered as the thrombocytosis group. Compared with the normal group, the detection rates of respiratory syncytial virus (RSV) and human rhinovirus (HRV) were significantly higher in the thrombocytosis group (P = 0.017 and 0.042, respectively). HRV single infection was a risk factor associated with thrombocytosis [odds ratio (OR) = 1.560, 95% confidence interval (CI) = 1.108-2.197]. Furthermore, ST was more likely to occur in younger patients who had clinical manifestations of wheezing and dyspnea and who had been diagnosed with bronchiolitis. Furthermore, the course of disease lasted longer in these patients. ST is associated with viral respiratory tract infections, especially RSV and HRV infections. HRV single infection is a risk factor associated with thrombocytosis.
继发性血小板增多症（ST）常见于患有各种临床病症的儿童。儿童ST的主要病因是呼吸道感染（RTI）。收集鼻咽抽吸物样本并评估常见呼吸道病毒。回顾性分析病毒感染与继发性血小板增多症之间的关系。对3156例RTI患者测定血小板计数和呼吸道病毒的存在情况，817例（25.9%）血小板≥500×10⁹/L的病例被视为血小板增多症组。与正常组相比，血小板增多症组呼吸道合胞病毒（RSV）和人鼻病毒（HRV）的检出率显著更高（分别为P = 0.017和0.042）。HRV单一感染是与血小板增多症相关的危险因素[比值比（OR）= 1.560，95%置信区间（CI）= 1.108 - 2.197]。此外，ST更易发生于有喘息和呼吸困难临床表现且被诊断为细支气管炎的较年轻患者。此外，这些患者的病程持续时间更长。ST与病毒性呼吸道感染相关，尤其是RSV和HRV感染。HRV单一感染是与血小板增多症相关的危险因素。
