肥胖是人体内血浆脂质过氧化和红细胞细胞保护酶消耗的独立危险因素。

Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans.

作者信息

Olusi S O

机构信息

Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.

出版信息

Int J Obes Relat Metab Disord. 2002 Sep;26(9):1159-64. doi: 10.1038/sj.ijo.0802066.

DOI:10.1038/sj.ijo.0802066

PMID:12187391

Abstract

OBJECTIVE

Obesity, defined as a body mass index (BMI) greater than 30 kg/m(2), is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans.

SUBJECTS

Fifty normal healthy subjects with healthy BMI (19-25 kg/m(2)) and 250 subjects with different grades of obesity (30-50 kg/m(2)) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer.

MEASUREMENTS

To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX).

RESULTS

The concentration of P-MDA was significantly lower (P<0.001) in subjects with healthy BMI (2.53+/-0.04 micro mol/l) than in those with BMI above 40 kg/m(2) (4.75+0.05 micro mol/l). Furthermore, there was a significantly positive association (r=0.342, P=0.013) between BMI and P-MDA. On the other hand, subjects with healthy BMI had significantly higher (P<0.001) erythrocyte CUZn-SOD (1464+/-23 units/g Hb) and GPX (98.4+/-3.3 units/g Hb) than those with BMI above 40 kg/m(2) (1005+/-26 units/g Hb) and (84.3+/-6.7 units/g Hb) respectively. Furthermore, erythrocyte CuZn-SOD and GPX activities were negatively associated with BMI (r=-0.566, P=0.005 and r=-0.436, P=0.018) respectively.

CONCLUSION

It is concluded from these results that obesity in the absence of smoking, diabetes mellitus, hyperlipidaemia, renal or liver disease causes lipid peroxidation and decreased activities of cytoprotective enzymes, and should therefore receive the same attention as obesity with complications.

摘要

目的

肥胖定义为体重指数（BMI）大于30kg/m²，目前被认为是糖尿病、高脂血症、结肠癌、猝死及其他心血管疾病的危险因素。本研究假设肥胖是人类脂质过氧化及细胞保护酶活性降低的独立危险因素。

研究对象

50名BMI正常（19 - 25kg/m²）的健康受试者以及250名不同程度肥胖（30 - 50kg/m²）的受试者，这些受试者无吸烟史，且无糖尿病、高血压、高脂血症、肾脏或肝脏疾病或癌症的生化证据。

测量指标

为验证该假设，我们通过检测血浆丙二醛（P - MDA）浓度、红细胞铜锌超氧化物歧化酶（CuZn - SOD）及谷胱甘肽过氧化物酶（GPX）活性来评估脂质过氧化及细胞保护作用。

结果

BMI正常的受试者（2.53±0.04μmol/l）血浆丙二醛浓度显著低于BMI高于40kg/m²的受试者（4.75 + 0.05μmol/l）（P<0.001）。此外，BMI与P - MDA之间存在显著正相关（r = 0.342，P = 0.013）。另一方面，BMI正常的受试者红细胞CuZn - SOD（1464±23单位/g Hb）和GPX（98.4±3.3单位/g Hb）活性显著高于BMI高于40kg/m²的受试者，后者分别为（1005±26单位/g Hb）和（84.3±6.7单位/g Hb）（P<0.001）。此外，红细胞CuZn - SOD和GPX活性分别与BMI呈负相关（r = -0.566，P = 0.005和r = -0.436，P = 0.018）。