Cho Ching-Chang, Yen Gow-Chin, Lee Hsin-Yi, Tsai Chun-Tse, Chang Wei-Tang, Hsu Chin-Lin
Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
J Food Drug Anal. 2025 Mar 31;33(1):48-60. doi: 10.38212/2224-6614.3527.
This study investigated the preventive effects of a 40% ethanol extract of Hsian-tsao (40EEHT) on obesity in high-fat diet (HFD)-induced obese rats. Male Wistar rats were administered 0, 100, 200, or 500 mg/kg of 40EEHT, resulting in reduced body weight, total body fat, and hepatic tissue weight after 8 weeks. 40EEHT also decreased adipocyte size, improved lipid profiles, alleviated oxidative stress, and enhanced hepatic antioxidant enzyme activities. Additionally, it regulated fatty acid metabolism by reducing lipogenesis and increasing lipolysis and β-oxidation, suggesting its potential as an anti-obesity dietary supplement.
本研究调查了仙草40%乙醇提取物（40EEHT）对高脂饮食（HFD）诱导的肥胖大鼠肥胖的预防作用。给雄性Wistar大鼠分别灌胃0、100、200或500mg/kg的40EEHT，8周后体重、全身脂肪和肝脏组织重量均有所减轻。40EEHT还减小了脂肪细胞大小，改善了血脂谱，减轻了氧化应激，并增强了肝脏抗氧化酶活性。此外，它通过减少脂肪生成、增加脂肪分解和β-氧化来调节脂肪酸代谢，表明其作为抗肥胖膳食补充剂的潜力。
