El-Sayed Mahmoud S
Faculty of Science, Liverpool John Moores University, Henry Cotton Campus, Liverpool, UK.
Platelets. 2002 Aug-Sep;13(5-6):261-6. doi: 10.1080/0953770021000007221.
In recent years the involvement of platelets dysfunction in atherogenesis and in the clinical complications from atherosclerosis has become more recognised. Systemic platelet-related thrombogenic factors have been shown to be involved in the initiation and progression of atherogenesis and plaque growth. Over the last two decades, interest has been heightened regarding the changes in platelet aggregation and functions that are associated with exercise in normal subjects and also patients, particularly those suffering from coronary artery disease. Although exercise effects on platelet aggregation and function in healthy individuals have been examined, the results reported have been conflicting, most likely due to methodological problems in the measurements of platelet aggregation and activation during and after exercise. However for patients suffering from coronary heart disease, the balance of evidence available would strongly suggest that platelet aggregation and function are increased with exercise. Several drugs are known to affect platelets, the most studied among them is aspirin. The evidence available would suggest that aspirin is ineffective in attenuating enhanced platelet aggregation and activation induced by exercise. Although the effects of physical training have been briefly investigated, available meagre evidence suggests that exercise on a regular basis is associated with favourable effects on platelets aggregation and activation in both men and women.
近年来，血小板功能障碍在动脉粥样硬化形成及动脉粥样硬化临床并发症中的作用已得到更多认可。全身性血小板相关血栓形成因子已被证明参与动脉粥样硬化的起始、进展及斑块生长。在过去二十年中，人们对正常受试者以及患者（尤其是冠心病患者）运动相关的血小板聚集和功能变化的关注度不断提高。尽管已对运动对健康个体血小板聚集和功能的影响进行了研究，但报告的结果相互矛盾，这很可能是由于运动期间及运动后血小板聚集和活化测量中的方法学问题所致。然而，对于冠心病患者，现有证据有力地表明运动可增加血小板聚集和功能。已知有几种药物会影响血小板，其中研究最多的是阿司匹林。现有证据表明，阿司匹林在减轻运动诱导的血小板聚集增强和活化方面无效。尽管对体育锻炼的影响进行了简要研究，但现有少量证据表明，定期运动对男性和女性的血小板聚集和活化均有有益影响。
