Finnie John W, Blumbergs Peter C, Manavis Jim, Utteridge Tammy D, Gebski Val, Davies Ruth A, Vernon-Roberts Barrie, Kuchel Timothy R
Veterinary Services Division, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia.
Pathology. 2002 Aug;34(4):344-7. doi: 10.1080/003130202760120517.
To study the effect of long-term exposure to global system for mobile communication (GSM) radiofrequency fields on vascular permeability in murine brains.
Using a purpose-designed exposure system at 900 MHz, mice were given a 60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks at specific absorption rates (SAR) of 0.25, 1.0,2.0 and 4.0 W/kg. Control mice were sham-exposed or permitted free movement in a cage to evaluate any stress-related effects. Albumin immunohistochemistry was used to detect increased vascular permeability and the efficacy of the vascular tracer was confirmed with a positive control group exposed to a clostridial toxin known to increase vascular permeability in the brain.
In all exposed and control groups, albumin extravasation was minimal, often leptomeningeal, and was deemed insignificant as a maximum of three capillaries or venules in a given brain showed leakage from the very many blood vessels present in the three coronal brain sections.
These results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level using endogenous albumin as a vascular tracer.
研究长期暴露于全球移动通信系统（GSM）射频场对小鼠脑血管通透性的影响。
使用专门设计的900MHz暴露系统，以0.25、1.0、2.0和4.0W/kg的比吸收率（SAR），每周5天，每天对小鼠进行60分钟的远场全身暴露，持续104周。对照小鼠接受假暴露或允许在笼中自由活动，以评估任何与应激相关的影响。采用白蛋白免疫组织化学法检测血管通透性增加情况，并用已知可增加脑内血管通透性的梭菌毒素暴露阳性对照组来确认血管示踪剂的有效性。
在所有暴露组和对照组中，白蛋白外渗极少，通常位于软脑膜，鉴于在给定脑的三个冠状脑切片中存在大量血管，最多只有三条毛细血管或小静脉显示渗漏，故认为其无显著意义。
这些结果表明，使用内源性白蛋白作为血管示踪剂，在光学显微镜水平下，长期暴露于移动电话类型的辐射对血脑屏障完整性的破坏可忽略不计。
