Jones Glenn W, Kacinski Barry M, Wilson Lynn D, Willemze Rein, Spittle Margaret, Hohenberg Gerda, Handl-Zeller Leonore, Trautinger Franz, Knobler Robert
Department of Radiation Oncology, Cancer Care Ontario, Hamilton, Canada.
J Am Acad Dermatol. 2002 Sep;47(3):364-70. doi: 10.1067/mjd.2002.123482.
Radiotherapy has been successfully implemented in the treatment of mycosis fungoides (MF) for almost a century. With the development of the modern linear accelerator, it has become possible to treat extended areas of the skin with accelerated electrons. Total skin electron beam radiation (TSEB) has been in use for several decades, and a number of technical modifications have been made with the goals of optimizing dose distribution and improving clinical outcome. Emerging evidence from recent studies suggests an association between TSEB techniques and efficacy in the treatment of MF. Based on this evidence, the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group, in association with experts from radiotherapy centers in North America, has reached a consensus on acceptable methods and clinical indications for TSEB in the treatment of MF. The aims of this report are to enhance accessibility of this highly efficacious treatment modality to patients with MF and to provide a point of reference for further clinical research.
放射治疗已成功应用于蕈样肉芽肿（MF）的治疗近一个世纪。随着现代直线加速器的发展，利用加速电子治疗大面积皮肤成为可能。全身皮肤电子束放疗（TSEB）已应用数十年，为优化剂量分布和改善临床疗效进行了多项技术改进。近期研究的新证据表明TSEB技术与MF治疗疗效之间存在关联。基于这一证据，欧洲癌症研究与治疗组织皮肤淋巴瘤项目组与北美放疗中心的专家就TSEB治疗MF的可接受方法和临床适应症达成了共识。本报告的目的是提高MF患者对这种高效治疗方式的可及性，并为进一步的临床研究提供参考。
