Zhu Yifeng, Lu Baozhu, Byrd Brook, Chen Lisha, Xiong Emily, Plastaras John P, LaRiviere Michael, Pogue Brian W, Zhu Timothy C
Dept. of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104.
Dept. of Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705.
Proc SPIE Int Soc Opt Eng. 2025 Jan;13299. doi: 10.1117/12.3046423. Epub 2025 Mar 19.
Cherenkov imaging is a valuable tool for quality assurance of dose homogeneity in total skin electron therapy (TSET), where patients are treated in six postures using the Stanford technique. Cherenkov signals emitted from the patient's surface are captured, corrected, converted into 2D dose maps, and projected onto the body to generate a 3D pseudo dose distribution. This study aims to improve the accuracy of Cherenkov-converted doses by applying patient-specific generic correction factors derived from Monte Carlo simulations using finite element meshes (FEMs) reconstructed from 3D scans. A clinical study involving eight patients compared the corrected Cherenkov dose with in-vivo dosimetry (IVD) measurements. After applying generic corrections, the Cherenkov-converted dose showed good agreement with IVD, particularly in the shins, with discrepancies within 10%.
切伦科夫成像对于全身皮肤电子线治疗（TSET）中剂量均匀性的质量保证是一种有价值的工具，在TSET中，患者采用斯坦福技术以六种姿势接受治疗。从患者体表发出的切伦科夫信号被捕获、校正，转换为二维剂量图，并投影到身体上以生成三维伪剂量分布。本研究旨在通过应用从使用三维扫描重建的有限元网格（FEM）进行的蒙特卡罗模拟得出的患者特异性通用校正因子，提高切伦科夫转换剂量的准确性。一项涉及八名患者的临床研究将校正后的切伦科夫剂量与体内剂量测定（IVD）测量结果进行了比较。应用通用校正后，切伦科夫转换剂量与IVD显示出良好的一致性，尤其是在小腿部位，差异在10%以内。
