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用于全身皮肤电子线治疗剂量评估的3D打印体模的研制

Development of a 3D-printed phantom for total skin electron therapy dose assessment.

作者信息

Lee Andrew, Alkhatib Zaid, Ibrahim Mounir, McCallum-Hee Broderick, Dass Joshua, Fernandez de Viana Matthew, Rowshanfarzad Pejman

机构信息

School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia.

Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

出版信息

J Appl Clin Med Phys. 2024 Dec;25(12):e14520. doi: 10.1002/acm2.14520. Epub 2024 Sep 16.

Abstract

PURPOSE

Total skin electron therapy (TSET) is a complex radiotherapy technique, posing challenges in commissioning and quality assurance (QA), especially due to significant variability in patient body shapes. Previous studies have correlated dose with factors such as obesity index, height, and gender. However, current treatment planning systems cannot simulate TSET plans, necessitating heavy reliance on QA methods using standardized anthropomorphic phantoms and in-vivo dosimetry. Given the relatively few studies on rotational techniques, comprehensive data in commissioning could streamline the process.

METHODS

Developing a full-body phantom would enable a more thorough TSET commissioning process, including testing for position-specific dose distributions and comprehensive measurements across all body surfaces, unlike the typical torso-only phantoms. This was created using digital modeling software, fabricated using 3D-printing FDM technology, and filled with tissue-equivalent gelatine. The phantom was positioned at an SSD of 340 cm and irradiated with a standard rotational TSET plan using the 6E HDTSE mode on a Varian TrueBeam linac at gantry angles of ± 18° from the horizontal. The dose was measured at over 50 points across the surface using Gafchromic EBT3 film.

RESULTS

Dose distributions were generally consistent with existing literature values from in-vivo dosimetry, with several position-specific differences identified, including the hands and scalp compared to conventional positions. Hotspots were observed for the mid-dorsum of the foot and nose, with areas under 80% of the dose identified as the soles of the feet, perineum, vertex of the scalp, top of the shoulder, and palm of the hand. Additionally, analysis using an interpolated dose heatmap found that 90% of the pixel area received a dose within 10% of the prescribed dose, indicating good uniformity with the commissioned technique.

CONCLUSIONS

With high agreement with the current literature, a 3D-printed phantom proves effective for measuring doses in areas typically unmeasurable in TSET commissioning.

摘要

目的

全身电子线治疗(TSET)是一种复杂的放射治疗技术,在设备调试和质量保证(QA)方面面临挑战,尤其是由于患者体型存在显著差异。先前的研究已将剂量与肥胖指数、身高和性别等因素相关联。然而,当前的治疗计划系统无法模拟TSET计划,因此严重依赖使用标准化人体模型和体内剂量测定的QA方法。鉴于关于旋转技术的研究相对较少,调试过程中的全面数据可以简化这一流程。

方法

与典型的仅针对躯干的模型不同,开发一个全身模型将使TSET调试过程更加全面,包括测试特定位置的剂量分布以及对所有身体表面进行全面测量。这是使用数字建模软件创建的,采用3D打印熔融沉积成型(FDM)技术制造,并填充组织等效明胶。该模型放置在源皮距(SSD)为340 cm处,在Varian TrueBeam直线加速器上使用6E HDTSE模式,以相对于水平方向±18°的机架角度,用标准旋转TSET计划进行照射。使用Gafchromic EBT3胶片在表面的50多个点测量剂量。

结果

剂量分布总体上与体内剂量测定的现有文献值一致,发现了一些特定位置的差异,包括与传统位置相比的手部和头皮。在足背中部和鼻部观察到热点,剂量低于80%的区域被确定为脚底、会阴、头皮顶点、肩部顶部和手掌。此外,使用插值剂量热图分析发现,90%的像素区域接受的剂量在规定剂量的10%以内,表明该调试技术具有良好的均匀性。

结论

与当前文献高度一致,3D打印模型被证明对于测量TSET调试中通常无法测量区域的剂量是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1d/11633812/706ee7db0ead/ACM2-25-e14520-g005.jpg

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