Melov Simon
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.
Int J Biochem Cell Biol. 2002 Nov;34(11):1395-400. doi: 10.1016/s1357-2725(02)00086-9.
Oxidative stress is a ubiquitous phenomena in all cell types, and it is primarily produced in mitochondria which are essential for multicellular life. Oxidative stress targets can be wide ranging and include nucleic acids and a variety of macromolecules. This review discusses the role of oxidative stress in the context of animal models, focusing in particular on animal models of aging, as well as the development of a new class of therapeutic small molecular weight antioxidants that have proven effective in extending the lifespan of a simple invertebrate nematode.
氧化应激是所有细胞类型中普遍存在的现象，它主要在线粒体中产生，而线粒体对于多细胞生物的生命至关重要。氧化应激的靶点范围广泛，包括核酸和多种大分子。本综述讨论了氧化应激在动物模型中的作用，尤其关注衰老动物模型，以及一类新型治疗性小分子抗氧化剂的开发，这类抗氧化剂已被证明能有效延长一种简单无脊椎动物线虫的寿命。
