Sun Yao, Kiani Mohammad F, Postlethwaite Arnold E, Weber Karl T
Division of Cardiovascular Diseases, University of Tennessee, Health Science Center, Rm 353 Dobbs Research Institute, 951 Court Avenue, Memphis, TN 38163, USA.
Basic Res Cardiol. 2002 Sep;97(5):343-7. doi: 10.1007/s00395-002-0365-8.
Infarct scar tissue has long been considered inert (acellular, composed simply of fibrillar collagen) and whose function is simply to restore structural integrity to infarcted myocardium and to provide tensile strength that prevents tissue rupture. Technologies of cellular and molecular biology have altered this perspective. Infarct scar is now recognized as living tissue: composed of a persistent population of fibroblast-like cells whose ongoing activity includes a regulation of collagen turnover and scar tissue contraction and which are nourished by a neovasculature. Herein we briefly review these various components of the infarct scar that provide for its dynamic nature and which is relevant to today's interest in preventing heart failure through a rebuilding (regrowing) of myocardial tissue at the infarct size.
长期以来，梗死瘢痕组织一直被认为是无活性的（无细胞，仅由纤维状胶原蛋白组成），其功能仅仅是恢复梗死心肌的结构完整性，并提供防止组织破裂的抗张强度。细胞和分子生物学技术改变了这一观点。现在人们认识到梗死瘢痕是活组织：由一群持续存在的成纤维细胞样细胞组成，其持续活动包括调节胶原蛋白周转和瘢痕组织收缩，并且由新生血管提供营养。在此，我们简要回顾梗死瘢痕的这些不同组成部分，它们赋予了梗死瘢痕动态特性，并且与当今通过在梗死区域重建（再生）心肌组织来预防心力衰竭的研究兴趣相关。
