Stein Michael D, Charuvastra Anthony, Anderson Bradley, Sobota Mindy, Friedmanna Peter D
Brown University School of Medicine, Providence, RI, USA.
Addict Behav. 2002 Sep-Oct;27(5):727-36. doi: 10.1016/s0306-4603(01)00205-2.
To determine if drug risk days are also alcohol use days for active injection drug users (IDUs).
Cross-sectional interview of 187 AUDIT-positive (> or = 8) active IDUs recruited between 2/98 and 10/99 from a needle exchange program (NEP) in Providence, RI. A drug risk day is defined as "using needles, cotton, or cookers after someone else had used it," measured using a 30-day Timeline Follow-Back procedure.
The sample was 64% male, 87% white, with 85% meeting DSM-IV criteria for alcohol abuse/dependence. Of the total days analyzed (n = 5610), 25% were drug risk days; on 40% of these days, drinking also occurred. Using a generalized estimating equation (GEE) model to cluster by subject, alcohol use was associated with drug risk days (OR 1.53; 95% CI 1.2-1.9; P < .001), controlling for gender, age, race, cocaine use, number of daily injections, methadone treatment, and partner drug use.
Using a data analytic strategy that allows examination of self-reports of behaviors on a day-to-day basis, we found that alcohol use is associated with drug risk taking behavior among IDUs. Whether alcohol use precedes or is subsequent to risky HIV behaviors remains to be determined.
确定对于活跃的注射吸毒者(IDU)而言,药物风险日是否也是饮酒日。
对187名酒精使用障碍识别测试(AUDIT)阳性(≥8分)的活跃IDU进行横断面访谈,这些人于1998年2月至1999年10月间从罗德岛州普罗维登斯的一个针头交换项目(NEP)招募而来。药物风险日被定义为“在他人使用过之后使用针头、棉花或炊具”,通过30天时间线回溯程序进行测量。
样本中64%为男性,87%为白人,85%符合DSM - IV酒精滥用/依赖标准。在分析的总天数(n = 5610)中,25%为药物风险日;在这些日子里,40%也有饮酒行为。使用广义估计方程(GEE)模型按个体进行聚类分析,在控制了性别、年龄、种族、可卡因使用、每日注射次数、美沙酮治疗和伴侣药物使用情况后,饮酒与药物风险日相关(比值比1.53;95%置信区间1.2 - 1.9;P < 0.001)。
通过一种允许逐日检查行为自我报告的数据分析策略,我们发现饮酒与IDU中的药物冒险行为相关。饮酒是先于还是后于有风险的HIV行为仍有待确定。