Rowe J Alexandra, Obiero Jack, Marsh Kevin, Raza Ahmed
Institute of Cell, Animal and Population Biology, University of Edinburgh, UK.
Am J Trop Med Hyg. 2002 May;66(5):458-60. doi: 10.4269/ajtmh.2002.66.458.
Plasmodium falciparum isolates that form rosettes with uninfected red cells are associated with severe malaria in African children, although the mechanism by which rosetting contributes to severe disease is unknown. Here we have analyzed the relationship between rosetting and parasitemia in two samples of clinical isolates from children with malaria in Kilifi, Kenya. A consistent positive correlation was found between rosetting and parasitemia (Spearman's rank correlation coefficent p = 0.467, P < .001, n = 154, for 1993 study; p = .407, P < .001, n = 74, for 2000 study). Rosetting may enhance parasite growth and survival by facilitating invasion or promoting immune evasion, thus allowing higher parasitemia to develop and increasing the likelihood of severe malaria.
与未感染红细胞形成花环状的恶性疟原虫分离株与非洲儿童的严重疟疾有关，尽管形成花环状导致严重疾病的机制尚不清楚。在这里，我们分析了肯尼亚基利菲患有疟疾的儿童的两个临床分离株样本中花环状与寄生虫血症之间的关系。在花环状与寄生虫血症之间发现了一致的正相关（1993年研究中，Spearman等级相关系数p = 0.467，P <.001，n = 154；2000年研究中，p =.407，P <.001，n = 74）。形成花环状可能通过促进入侵或促进免疫逃避来增强寄生虫的生长和存活，从而使更高的寄生虫血症得以发展，并增加严重疟疾的可能性。
