Wahlgren M, Carlson J, Ruangjirachuporn W, Conway D, Helmby H, Martinez A, Patarroyo M E, Riley E
University of Stockholm, Sweden.
Am J Trop Med Hyg. 1990 Oct;43(4):333-8. doi: 10.4269/ajtmh.1990.43.333.
Uninfected erythrocytes bind spontaneously to those infected with certain strains of Plasmodium falciparum. This is known as spontaneous erythrocyte rosetting. We have studied the occurrence and frequency of rosetting in 75 fresh patient isolates and have identified rosetting strains from Africa, South America, and Asia. Rosetting was present in 49% of the isolates tested; the frequency of rosetting red blood cells (RBC) in individual isolates was 0-75% when scored during the first cycle of in vitro growth. Rosetting antibodies were found in 15 out of 73 (21%) Liberian sera as measured by disruption of rosettes in vitro. However, antibodies able to inhibit CD36 dependent cytoadherence of P. falciparum-infected RBC were not detected in these sera. Erythrocyte rosetting is a geographically widespread phenomenon. Rosetting antibodies seem to be induced by natural infection and the molecular mechanism of rosette formation seems distinct from that of endothelial cytoadherence.
未感染的红细胞会自发地与感染某些恶性疟原虫菌株的红细胞结合。这被称为自发红细胞玫瑰花结形成。我们研究了75株新鲜患者分离株中玫瑰花结形成的发生率和频率，并鉴定出了来自非洲、南美洲和亚洲的玫瑰花结形成菌株。在所测试的分离株中，49%出现了玫瑰花结形成；在体外生长的第一个周期进行评分时，单个分离株中玫瑰花结红细胞（RBC）的频率为0 - 75%。通过体外破坏玫瑰花结来测量，在73份利比里亚血清中有15份（21%）发现了玫瑰花结抗体。然而，在这些血清中未检测到能够抑制恶性疟原虫感染的RBC的CD36依赖性细胞黏附的抗体。红细胞玫瑰花结形成是一种在地理上广泛存在的现象。玫瑰花结抗体似乎是由自然感染诱导的，并且玫瑰花结形成的分子机制似乎与内皮细胞黏附的机制不同。
