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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Barbiroli B, Bovina C, Tolomelli B, Marchetti M

Biochem J. 1975 Nov;152(2):229-32. doi: 10.1042/bj1520229.

Folate metabolism was studied during the early phases of liver regeneration after partial hepatectomy in rats accustomed to eating during the first 8h of a daily 12h dark period. 2. The content of 5-CH(3)-H(4)folate was drastically decreased during the first hours of regeneration. 3. The total HCO-H(4)folate coenzymes showed a constant decrease during the first 3 days of regeneration, and a continuous interconversion between 5-HCO-H(4)folate and 10-HCO-H(4)folate. 4. 10-HCO-H(4)folate synthetase, serine hydroxymethyl-transferase and 5,10-CH(2)-H(4)folate dehydrogenase activities were relatively low during the first hours after the operation, and increased only several hours later. 5. The increase in enzyme activities showed a stepwise pattern, apparently due to an interaction between the regeneration process and the controlled feeding schedules.

在部分肝切除术后大鼠肝脏再生的早期阶段，对习惯于在每日12小时黑暗期的前8小时进食的大鼠的叶酸代谢进行了研究。2. 在再生的最初几个小时内，5-CH(3)-H(4)叶酸的含量急剧下降。3. 在再生的前3天，总HCO-H(4)叶酸辅酶持续下降，且5-HCO-H(4)叶酸和10-HCO-H(4)叶酸之间存在持续的相互转化。4. 10-HCO-H(4)叶酸合成酶、丝氨酸羟甲基转移酶和5,10-CH(2)-H(4)叶酸脱氢酶的活性在手术后的最初几个小时相对较低，仅在数小时后增加。5. 酶活性的增加呈现出逐步的模式，显然是由于再生过程与控制进食时间表之间的相互作用。

Barbiroli B, Bovina C, Tolomelli B, Marchetti M

Biochem J. 1975 Nov;152(2):229-32. doi: 10.1042/bj1520229.

Folate metabolism was studied during the early phases of liver regeneration after partial hepatectomy in rats accustomed to eating during the first 8h of a daily 12h dark period. 2. The content of 5-CH(3)-H(4)folate was drastically decreased during the first hours of regeneration. 3. The total HCO-H(4)folate coenzymes showed a constant decrease during the first 3 days of regeneration, and a continuous interconversion between 5-HCO-H(4)folate and 10-HCO-H(4)folate. 4. 10-HCO-H(4)folate synthetase, serine hydroxymethyl-transferase and 5,10-CH(2)-H(4)folate dehydrogenase activities were relatively low during the first hours after the operation, and increased only several hours later. 5. The increase in enzyme activities showed a stepwise pattern, apparently due to an interaction between the regeneration process and the controlled feeding schedules.

在部分肝切除术后大鼠肝脏再生的早期阶段，对习惯于在每日12小时黑暗期的前8小时进食的大鼠的叶酸代谢进行了研究。2. 在再生的最初几个小时内，5-CH(3)-H(4)叶酸的含量急剧下降。3. 在再生的前3天，总HCO-H(4)叶酸辅酶持续下降，且5-HCO-H(4)叶酸和10-HCO-H(4)叶酸之间存在持续的相互转化。4. 10-HCO-H(4)叶酸合成酶、丝氨酸羟甲基转移酶和5,10-CH(2)-H(4)叶酸脱氢酶的活性在手术后的最初几个小时相对较低，仅在数小时后增加。5. 酶活性的增加呈现出逐步的模式，显然是由于再生过程与控制进食时间表之间的相互作用。