Szlachcic Yaga, Adkins Rodney H, Waters Robert L, Govindarajan Sugantha, Wang Jiangnan, Yee Florence, Greenwood John
Departments of Medicine, Rancho Los Amigos National Rehabilitation Center, Downey, California 90242, USA.
J Spinal Cord Med. 2002 Fall;25(3):156-60. doi: 10.1080/10790268.2002.11753616.
Elevated plasma levels of creatine kinase (CPK) are found in various neuromuscular conditions as a result of muscle damage and necrosis. Elevated CPK has also been described in elite wheelchair athletes and in able-bodied individuals after strenuous exercise.
The incidence of elevated CPK in individuals with spinal cord injury (SCI) has not been well established. We reviewed laboratory data from 581 individuals with chronic SCI.
Most individuals with SCI (73.3%) had CPK values within 95% confidence intervals for able-bodied individuals. The highest levels were seen in African Americans (21% had CPK values > 95 confidence intervals for able-bodied individuals). Significant associations between CPK and the following independent variables were identified: impairment group, gender, duration of injury, body mass index, and ethnic group. Multiple regression analysis revealed significant correlations between CPK and oxygen consumption (beta .37, P < .01) in 32 individuals who performed the exercise test.
These findings are important for clinicians evaluating symptoms of fatigue and myopathy in individuals with SCI.
在各种神经肌肉疾病中，由于肌肉损伤和坏死，可发现血浆肌酸激酶（CPK）水平升高。在精英轮椅运动员和剧烈运动后的健全个体中也有CPK升高的描述。
脊髓损伤（SCI）个体中CPK升高的发生率尚未明确。我们回顾了581例慢性SCI个体的实验室数据。
大多数SCI个体（73.3%）的CPK值在健全个体的95%置信区间内。非裔美国人中CPK水平最高（21%的非裔美国人CPK值>健全个体的95%置信区间）。确定了CPK与以下独立变量之间的显著关联：损伤组、性别、损伤持续时间、体重指数和种族。多元回归分析显示，在进行运动测试的32名个体中，CPK与耗氧量之间存在显著相关性（β=0.37，P<0.01）。
这些发现对于评估SCI个体疲劳和肌病症状的临床医生很重要。
