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过敏性紫癜性肾炎合并肺出血但治疗成功。

Henoch-Schönlein nephritis complicated with pulmonary hemorrhage but treated successfully.

作者信息

Al-Harbi Nafaa N

机构信息

King Faisal Specialist Hospital and Research Center, P.O. Box 40047, Jeddah 21499, Kingdom of Saudi Arabia.

出版信息

Pediatr Nephrol. 2002 Sep;17(9):762-4. doi: 10.1007/s00467-002-0926-y. Epub 2002 Jul 27.

Abstract

Henoch-Schönlein purpura (HSP) is a common vasculitic syndrome in children who, in most cases, achieve complete recovery. Occasionally, however, patients develop nephritis or nephrotic syndrome with renal failure, or develop significant gastrointestinal bleeding. Pulmonary hemorrhage, found mostly in adolescents and adults, and with a high mortality rate, has been reported only in a few prepubertal children, with a slightly better outcome. A 9-year-old-girl with HSP, renal failure, and nephrotic syndrome developed severe bilateral pulmonary hemorrhage. After an unsuccessful trial of glucocorticoid therapy, she showed an excellent response to cytotoxic therapy.

摘要

过敏性紫癜(HSP)是儿童常见的血管炎综合征,大多数情况下可完全康复。然而,偶尔患者会发展为肾炎或肾病综合征并伴有肾衰竭,或出现严重的胃肠道出血。肺出血多见于青少年和成人,死亡率高,仅在少数青春期前儿童中有报道,预后稍好。一名患有过敏性紫癜、肾衰竭和肾病综合征的9岁女孩发生了严重的双侧肺出血。在糖皮质激素治疗试验失败后,她对细胞毒性治疗表现出良好反应。

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