Vats K R, Vats A, Kim Y, Dassenko D, Sinaiko A R
Department of Pediatrics, University of Minnesota, Minneapolis 55455-0392, USA.
Pediatr Nephrol. 1999 Aug;13(6):530-4. doi: 10.1007/s004670050652.
Pulmonary hemorrhage, a rare complication of Henoch-Schönlein purpura (HSP) reported primarily in adults and adolescents, is associated with significant mortality. Although it has been suggested that pulmonary hemorrhage also occurs in children with HSP, the few cases reported lack a clear differentiation from pauci-immune vasculitis. We report a prepubertal child with HSP, pulmonary hemorrhage, and immunofluorescence-documented IgA deposits on renal biopsy. Aggressive supportive management and steroid therapy led to successful recovery. A review of the current literature is presented. Because other conditions clinically mimic HSP, appropriate serological studies and a kidney biopsy to confirm the diagnosis should be performed in severely affected patients with renal disease.
肺出血是过敏性紫癜（HSP）的一种罕见并发症，主要在成人和青少年中报道，与显著的死亡率相关。尽管有人提出HSP患儿也会发生肺出血，但所报道的少数病例与寡免疫性血管炎缺乏明确区分。我们报告了一名青春期前患有HSP、肺出血且肾活检有免疫荧光证实的IgA沉积的儿童。积极的支持治疗和类固醇治疗导致其成功康复。本文对当前文献进行了综述。由于其他疾病在临床上可模仿HSP，对于患有严重肾脏疾病的患者，应进行适当的血清学研究和肾活检以确诊。
