Lovas Kornélia, Géher Pál, Whalley Diane, McKenna Stephen, Meads David, Kaló Zoltán
Semmelweis Egyetem, Altalános Orvostudományi Kar, Egyetemi Gyógyszertár és Gyógyszerügyi Intézet, Budapest.
Orv Hetil. 2002 Aug 11;143(32):1893-7.
Measuring quality of life has growing importance in the field of health technology assessment. It is especially true for chronic diseases, like ankylosing spondylitis, which results in significant impact on patients' quality of life through the intensity and duration of the disease.
To measure the reliability and validity of the Hungarian version of Ankylosing Spondylitis Quality of Life instrument with the intention of its use in clinical and health economic trials and burden of disease studies in Hungary via the introduction of a certain validation process.
One of the most important criteria for the validity of quality of life instruments is the standard method used for adapting the questionnaire to foreign languages. The dual method was applied for the Hungarian adaptation of the Ankylosing Spondylitis Quality of Life questionnaire, which was followed by psychometric testing.
High test-retest correlation (0.85) indicated an acceptable degree of reliability with no evidence of excessive random measurement error. The internal consistency of the measure was confirmed (Cronbach's alpha coefficients were 0.87 and 0.91 at Time 1 and Time 2 respectively), with strong evidence that all items were adequately inter-related. The correlations with the NHP at both time points were at the expected levels, providing evidence of convergent and divergent validity.
On the basis of results shown above, it is concluded that the Hungarian Ankylosing Spondylitis Quality of Life questionnaire is a reliable and valid measure of quality of life.
在卫生技术评估领域，生活质量测量的重要性日益凸显。对于像强直性脊柱炎这样的慢性病来说尤其如此，该病通过疾病的强度和持续时间对患者的生活质量产生重大影响。
通过引入特定的验证过程，测量匈牙利语版强直性脊柱炎生活质量量表的信度和效度，以便在匈牙利的临床和卫生经济试验以及疾病负担研究中使用。
生活质量量表效度的最重要标准之一是将问卷改编为外语所使用的标准方法。对强直性脊柱炎生活质量问卷进行匈牙利语改编时采用了双重方法，随后进行了心理测量测试。
重测相关性较高（0.85），表明信度可接受，且没有过度随机测量误差的证据。该测量方法的内部一致性得到证实（Cronbach's alpha系数在时间1和时间2分别为0.87和0.91），有力证据表明所有项目之间具有充分的相互关联性。两个时间点与诺丁汉健康量表（NHP）的相关性均处于预期水平，提供了收敛效度和区分效度的证据。
基于上述结果，得出结论：匈牙利语版强直性脊柱炎生活质量问卷是一种可靠且有效的生活质量测量工具。
