Covaci Adrian, Koppen Gudrun, Van Cleuvenbergen Rudy, Schepens Paul, Winneke Gerhard, van Larebeke Nicolas, Nelen Vera, Vlietinck Robert, Schoeters Greet
Toxicological Center, University of Antwerp, Antwerpen (Wilrijk), Belgium.
Chemosphere. 2002 Sep;48(8):827-32. doi: 10.1016/s0045-6535(02)00112-1.
In 1999, the FLEHS was set by the Flemish Ministry of Health, Belgium to assess pollutant concentrations and related health effect biomarkers in humans living in Flanders. Concentrations of selected organochlorine pesticides, polychlorinated biphenyls (PCB) and polychlorinated dibenzo-p-dioxins (PCDD) and furans (PCDF) were measured by gas chromatography-mass spectrometry and Chemical-Activated LUciferase gene eXpression (CALUX) bioassay in 47 serum pools of 200 women between 50 and 65 years living in two areas of Flanders. Correlation between TEQ values of different groups of compounds were computed in these pool results and it was found that total toxic equivalencies (TEQs) correlated well with the values of the groups of contributing compounds: mono-ortho PCBs (r = 0.77), non-ortho PCBs (r = 0.65) and PCDD/Fs (r = 0.88). The total TEQ was lower correlated to the CALUX-TEQ (r = 0.57). When calculating associations between those classes of compounds in the two studied regions separately, they were all higher correlated in the urban area compared to the more rural region. High correlation coefficients (r > 0.80) were also calculated between individual compounds and groups of compounds. It was suggested that in this studied background-exposed population, some compounds could be good predictors for a group: e.g. PCB 153 for indicator and total PCBs, PCB 118 for total PCB TEQ, PCB 156 for mono-ortho PCB-TEQs and total TEQ, 2,3,4,7,8-P5CDF for PCDD/F TEQs and total TEQs. This means that in pooled serum samples correlations between persistent organochlorine compounds are as strong as for individual POP measurements observed in earlier studies.
1999年，比利时弗拉芒大区卫生部设立了弗拉芒大区环境与健康研究（FLEHS），以评估居住在弗拉芒大区的人群体内污染物浓度及相关健康效应生物标志物。通过气相色谱-质谱联用仪和化学激活荧光素酶基因表达（CALUX）生物测定法，对居住在弗拉芒大区两个地区的47组血清样本（每组包含200名年龄在50至65岁之间的女性）中的选定有机氯农药、多氯联苯（PCB）以及多氯二苯并对二恶英（PCDD）和多氯二苯并呋喃（PCDF）的浓度进行了测量。在这些样本结果中计算了不同化合物组的毒性当量（TEQ）值之间的相关性，发现总毒性当量（TEQs）与各贡献化合物组的值具有良好的相关性：单邻位多氯联苯（r = 0.77）、非邻位多氯联苯（r = 0.65）和多氯二苯并对二恶英/多氯二苯并呋喃（r = 0.88）。总TEQ与CALUX-TEQ的相关性较低（r = 0.57）。分别计算两个研究区域中这些化合物类别的关联时，与农村地区相比，城市地区的相关性更高。还计算了单个化合物与化合物组之间的高相关系数（r > 0.80）。研究表明，在这个背景暴露人群中，某些化合物可能是一组化合物的良好预测指标：例如，PCB 153可作为指示物和总多氯联苯的指标，PCB 118可作为总PCB TEQ的指标，PCB 156可作为单邻位PCB-TEQs和总TEQ的指标，2,3,4,7,8-五氯二苯并呋喃可作为多氯二苯并对二恶英/多氯二苯并呋喃TEQs和总TEQs的指标。这意味着在混合血清样本中，持久性有机氯化合物之间的相关性与早期研究中观察到的单个持久性有机污染物测量结果的相关性一样强。
