小窝：从细胞生物学到动物生理学

Caveolae: from cell biology to animal physiology.

作者信息

Razani Babak, Woodman Scott E, Lisanti Michael P

机构信息

Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA.

出版信息

Pharmacol Rev. 2002 Sep;54(3):431-67. doi: 10.1124/pr.54.3.431.

DOI:10.1124/pr.54.3.431

PMID:12223531

Abstract

Among the membrane compartments of a cell, vesicles known as "caveolae" have long defied functional characterization. However, since the identification of a family of proteins termed "caveolins", that form and reside in caveolae, a better understanding has emerged. It is now clear that caveolae do not merely play a singular role in the cell, but are pleiotropic in nature-serving to modulate many cellular functions. The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.

摘要

在细胞的膜性区室中，一种被称为“小窝”的囊泡长期以来一直难以进行功能表征。然而，自从鉴定出一类称为“小窝蛋白”的蛋白质家族，它们形成并存在于小窝中，人们对其有了更好的理解。现在很清楚，小窝在细胞中不仅仅发挥单一作用，而是具有多效性——有助于调节许多细胞功能。本综述的目的是阐明关于小窝蛋白/小窝的已知信息，并突出小窝研究中不断发展的领域。