Alahari Suresh K, Reddig Peter J, Juliano R L
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599, USA.
Int Rev Cytol. 2002;220:145-84. doi: 10.1016/s0074-7696(02)20005-4.
Cell adhesion receptors such as integrins, cadherins, selectins, and immunoglobulin family receptors profoundly modulate many signal transduction cascades. In this review we examine aspects of adhesion receptor signaling and how this impinges on key biological processes. We have chosen to focus on cell migration and on programmed cell death. We examine many of the cytoplasmic signaling molecules that interface with adhesion receptors, including focal adhesion kinase (FAK), phosphatidylinositol-3-kinase (PI3K), and elements of the Erk/MAP kinase pathway. In many cases these molecules impinge on both the regulation of cell movement and on control of apoptosis.
整合素、钙黏蛋白、选择素和免疫球蛋白家族受体等细胞黏附受体深刻地调节着许多信号转导级联反应。在本综述中，我们研究了黏附受体信号传导的各个方面，以及这如何影响关键的生物学过程。我们选择专注于细胞迁移和程序性细胞死亡。我们研究了许多与黏附受体相互作用的细胞质信号分子，包括黏着斑激酶（FAK）、磷脂酰肌醇-3-激酶（PI3K）以及Erk/丝裂原活化蛋白激酶途径的元件。在许多情况下，这些分子既影响细胞运动的调节，也影响细胞凋亡的控制。
