Magnus Tim, Chan Andrew, Savill John, Toyka Klaus V, Gold Ralf
Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Julius-Maximilians-University, D-97080, Würzburg, Germany.
J Neuroimmunol. 2002 Sep;130(1-2):1-9. doi: 10.1016/s0165-5728(02)00212-6.
Apoptotic cell death of inflammatory T cells is an established mechanism to terminate an autoimmune inflammatory response in the rodent and human central nervous system (CNS). The efficient clearance of apoptotic cells protects the tissue from leakage of potentially harmful substances from secondary necrotic cells. As the resident phagocyte, the microglial cell is the primary candidate for the clearance of apoptotic lymphocytes. Furthermore, the phagocytosis of apoptotic cells is accompanied by a spectrum of anti-inflammatory effects. In this review, we focus on the mechanisms for removal of apoptotic inflammatory cells by microglia in the central nervous system and their functional consequences.
炎症性T细胞的凋亡性细胞死亡是啮齿动物和人类中枢神经系统（CNS）中终止自身免疫性炎症反应的既定机制。凋亡细胞的有效清除可保护组织免受继发性坏死细胞中潜在有害物质的泄漏。作为常驻吞噬细胞，小胶质细胞是清除凋亡淋巴细胞的主要候选者。此外，凋亡细胞的吞噬作用伴随着一系列抗炎作用。在本综述中，我们重点关注中枢神经系统中小胶质细胞清除凋亡炎症细胞的机制及其功能后果。
