来自福州薯蓣的生物活性皂苷。
Bioactive saponins from Dioscorea futschauensis.
作者信息
Liu H W, Hu K, Zhao Q C, Cui C B, Kobayashi H, Yao X S
机构信息
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, China.
出版信息
Pharmazie. 2002 Aug;57(8):570-2.
A new anti-neoplastic spirostanol saponin, (25S)-spirost-5-en-3 beta, 27-diol-3O-[alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranoside and three known compounds viz. prosapogenin A of dioscin, dioscin and gracilin were isolated from Dioscorea futschauensis by bioactivity-guided fractionation. Their structures were elucidated mainly by means of spectroscopic analysis. Their bioactivity against Pyricularia oryzae and cytotoxic activity on ts-FT210 cell line was evaluated.
通过生物活性导向分离法从薯蓣中分离出一种新的抗肿瘤螺甾烷醇皂苷，即(25S)-螺甾-5-烯-3β,27-二醇-3O-[α-L-鼠李糖基(1→2)-β-D-葡萄糖基(1→3)]-β-D-葡萄糖苷以及三种已知化合物，即薯蓣皂苷元A、薯蓣皂苷和纤细皂苷。主要通过光谱分析阐明了它们的结构。评估了它们对稻瘟病菌的生物活性以及对ts-FT210细胞系的细胞毒性活性。
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