来自玉竹根茎的甾体皂苷。

Steroidal saponins from the rhizomes of Polygonatum sibiricum.

作者信息

Ahn Mi-Jeong, Kim Chul Young, Yoon Kee-Dong, Ryu Min Youl, Cheong Jong Hye, Chin Young-Won, Kim Jinwoong

机构信息

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Korea.

出版信息

J Nat Prod. 2006 Mar;69(3):360-4. doi: 10.1021/np050394d.

DOI:10.1021/np050394d

PMID:16562835

Abstract

Four new steroidal saponins, named neosibiricosides A-D (1-4), were isolated from the rhizomes of Polygonatum sibiricum, along with two known spirostanol glycosides. The structures of the new glycosides were elucidated by spectroscopic methods and acid hydrolysis as (23S,24R,25R)-1-O-acetylspirost-5-ene-1beta,3beta,23,24-tetrol 3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->4)-beta-D-fucopyranoside (1), (25S)-1-O-acetylspirost-5-ene-1beta,3beta-diol 3-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside (2), (25S)-spirost-5-en-3beta-ol 3-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucopyranosyl-(1-->4)-2-O-acetyl-beta-D-galactopyranoside (3), and (25R,S)-spirost-5-en-3beta-ol 3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside (4). The cytotoxic activity of the isolated compounds was evaluated with human MCF-7 breast cancer cells.

摘要

从玉竹根茎中分离出四种新的甾体皂苷，命名为新西伯利亚苷A - D（1 - 4），以及两种已知的螺旋甾烷醇糖苷。通过光谱方法和酸水解确定了新糖苷的结构，分别为(23S,24R,25R)-1-O-乙酰基螺旋甾-5-烯-1β,3β,23,24-四醇3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃岩藻糖基糖苷（1）、(25S)-1-O-乙酰基螺旋甾-5-烯-1β,3β-二醇3-O-β-D-吡喃葡萄糖基-(1→2)-[β-D-吡喃木糖基-(1→3)]-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷（2）、(25S)-螺旋甾-5-烯-3β-醇3-O-β-D-吡喃葡萄糖基-(1→2)-[β-D-吡喃木糖基-(1→3)]-β-D-吡喃葡萄糖基-(1→4)-2-O-乙酰基-β-D-吡喃半乳糖苷（3）和(25R,S)-螺旋甾-5-烯-3β-醇3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷（4）。用人类MCF - 7乳腺癌细胞评估了分离出的化合物的细胞毒性活性。