Dong M, Feng X Z, Wang B X, Ikejima T, Wu L J
Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Ohio, USA.
Pharmazie. 2004 Apr;59(4):294-6.
A new steroidal saponin, dioscoreside E (1), and a known compound, protodioscin (2), were isolated from an ethanol extract of the rhizomes of Dioscorea panthaica. The structure of 1 was established as 3-O-[bis-alpha-L-rhamnopyranosyl-(1 --> 2 and 1 --> 4)-beta-D-glucopyranosyl]-26-O-beta-D-glucopyranosyl-20(R)-methoxy-25(R)-furosta-5,22(23)-diene-3beta,26-diol, on the basis of spectral and chemical evidence. Compounds 1 and 2 showed cytotoxic activity against a panel of tumor cell lines.
从黄山药根茎的乙醇提取物中分离得到一个新的甾体皂苷，薯蓣皂苷E（1）和一个已知化合物，原薯蓣皂苷（2）。基于光谱和化学证据，1的结构被确定为3-O-[双-α-L-鼠李吡喃糖基-(1→2和1→4)-β-D-吡喃葡萄糖基]-26-O-β-D-吡喃葡萄糖基-20(R)-甲氧基-25(R)-呋甾-5,22(23)-二烯-3β,26-二醇。化合物1和2对一组肿瘤细胞系显示出细胞毒性活性。
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